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Is It Cerebellar Hypoplasia or Cerebellar Abiotrophy?

January 23, 2013

If you thought the science behind cerebellar hypoplasia was complicated, just wait.

Photo courtesy Erik Nygren

I recently read about another condition that is so similar to CH that it is often confused for cerebellar hypoplasia. Consequently, there are times that vets sometimes diagnose this condition as CH, when it’s really not.

It’s called cerebellar abiotrophy.

It’s a disease that’s found in horses and dogs, much like CH, but it can also occur in cats, cattle and sheep, too. The condition’s symptoms are similar to CH, but the important difference is what causes this condition and when.

As you may know, cerebellar hypoplasia is a congenital condition resulting in the underdevelopment of the cerebellum, which is caused by the feline distemper virus or trauma while in utero. By and large CH occurs before a kitten is born, although there have been known to be a few exceptions.

Meanwhile, cerebellar abiotrophy is another type of cerebellar degeneration that occurs after the animal is born.

Cerebellar abiotrophy occurs when there is a loss of Purkinje cells in the cerebellum. These Purkinje cells, which affect balance and coordination, die off.

These cells are important because these cells allow the cerebellum’s different layers of the brain to communicate with one another. When they die off, that communication stops, and the animal can lose its sense of space and distance, as well as impacting its balance and coordination. 

From what I’ve read, it’s not entirely clear what causes this condition, but it’s thought to be caused by an “intrinsic metabolic defect.”

Photo courtesy Zillafag

If an animal has this defect, his Purkinje cells usually start to die off right after birth. The condition is usually noticeable before the animal is six-months old, although sometimes the cells die off more gradually, and an animal can be much older before the condition’s characteristics are noticeable.

Some of its symptoms include: ataxia, a wide-leg stance, and head tremors, which sounds a great deal like CH. But there are other symptoms that are more specific to CA, such as: hyperreactivity, lack of menace reflex, a stiff or high-stepping gait, jerky head-bob movements while in motion, poor depth perception, and a general inability to determine space and distance.

It sounds like the symptoms may worsen as the disease progresses, but some say it can stabilize over time. Like with CH, some animals with CA may actually learn to compensate and improve over time. Similarly, like CH, CA does not impact intelligence, and most animals can live out a normal lifespan.

7 Comments leave one →
  1. Monika Ross permalink
    July 2, 2013 7:52 am

    Our vet dx’d our 2 kittens with CH but he admitted that this was the 1st time he had actually seen CH – and he wasn’t sure. Since symptoms are the same what tests are needed to be performed to tell the difference?

    • July 4, 2013 10:41 am

      Hi Monika,
      Here’s a post that may help: http://lifewithchcats.com/2012/10/12/can-cerebellar-hypoplasia-be-officially-diagnosed/
      You may want to check out these related posts, too: http://lifewithchcats.com/tag/diagnosis/
      Good luck!

    • Monika Ross permalink
      July 4, 2013 1:26 pm

      Hello Amanda, Thank you for your response -unfortunetly we lost one of the kittens this morning. He became severly constipated and he died while at the vets. X-rays were taken and it appeared the he had a major bowel obstruction. There was no way we could have seen this coming . Although we only had him for 3 weeks he is already missed. His sister however is striving so far. They were approximately 6 weeks old and born to a feral mother who has made herself and her 2 other kittens at home in our garage. I will check out the links. Again Thank you for your response.
      Monika

    • July 6, 2013 9:18 am

      Hi Monika – I’m so sorry to hear about the kitten. I’m glad he was able to spend his final days with someone who cared so greatly for him.

  2. Monika Ross permalink
    July 5, 2013 3:04 pm

    Hello again Amanda, I just wanted to let you know to tell your readers that if ever you are not totally comfortable with your usual vet’s d,x to get a second opinion, even if it costs a little more. It will save heartbreak and money in the long run. Unfortunetly there are not enough vets around that know what CH is and how to deal with this. That was the problem in our situation. Apparently there is not enough info or training with this type of situation. We found that due to your website that we knew more than our vet. That is so sad if you know what I mean. Because we were afraid of what had happened to the male kitten we took the female sibling to another vet to have her checked out MORE thoroughly because she had an unusual urinary discharge. The r original vet stated he had no idea what it was. He thought it might possibly be a “tape worm” …. HUH?
    Although this problem has been based on the 2 CH kittens we rescued – this should hold true with with all “fur babies”. We have been Guardians/parents of both dogs and cats for over 40 years but we are still learning ( with our pocketbooks growing smaller and smaller all the time.) LOL
    Monika

  3. October 25, 2013 8:45 am

    It is such a relief to have finally found an article that mentions cerebellar abiotrophy (CA) in cats as there seems to be so little information available. My 5 year-old rescue cat, Elvis, was diagnosed with CA on MRI scan over 2 years ago. The scan was very expensive – 1700 GBP – but it was the only definitive test for this condition. The veterinary neurologist was unable to give a prognosis, only that there was no treatment and that he would deteriorate. Over the last two years his condition has indeed worsened, although he appears to have been stable for several months now. This certainly bears out the last paragraph of the article. Elvis can’t walk as his hind legs are not strong enough to support him. However, his front legs are fine. He can drag himself to the litter tray and to his food and water bowls without too much difficulty and with no pain or discomfort. He retains a huge zest for life (when he’s in the mood he is the best snuggler!) and he absolutely loves his food! This is all despite his other health problems – he has one eye (the other eye apparently became infected due to cat flu when he was a kitten and his owner rejected him) and occasional bouts of E. coli. Elvis is the most stoic of cats and I am very proud to be his servant!

    • Michelle Siptroth permalink
      November 30, 2013 3:18 pm

      Hi Faith, we have a seven month old kitten named Kuma who we adopted when she was 5 weeks old. We noticed head tremors and a slight lack of balance around 7 weeks of age. We knew nothing about CH but did a lot of online research and figured that this is what she had and when she was 4 months old the vet agreed. We kept saying mild CH for the first couple of months, but then Kuma seemed to continually worsen. Everything I read said CH does not worsen. She is now 7 months old and we think CA fits her description much more closely. Her eyes are not always dilated properly and she seems to lack depth and spacial perception. She used to run, climb, and jump. She now can only move her front front legs and drag her back ones like your “Elvis”. She can’t really get in the liter box so I put down towels with liter pads. She was using these but now seems to just “go” where ever she is and often falls into the mess. Daily baths are pretty regular for her but fortunately she seems to really enjoy them. Can you tell me about the liter tray you are using? I am looking for any tips that I can find. Kuma is very sweet and prefers to be held most of the the time. She sleeps in the bathroom at night and during the day when we are not at home because of her accidents. She is pretty mobile when she wants to be it just isn’t very often. I can’t find a lot of info on CA so any info you may have learned would be very helpful. Thanks so much, Michelle

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